Taking the functional data into account, one might hypothesize that a continuous loss of rich-club connectivity can only be compensated by peripheral connections in the early phase. Critical revision of the manuscript for important intellectual content: J.-P. However, preliminary data in RRMS indicate that the shift toward more peripheral connectivity is detectable within a time frame of 6 months and might be reduced by an exercise intervention. This newly defined mechanism confers protection from autoimmunity during pregnancy and represents a potential target for future therapy. From the Institut für Neuroimmunologie und Multiple Sklerose (INIMS) (J.-P. Thus, rich-club connectivity is a promising indicator for understanding and monitoring the patterns and mechanisms of neurodegeneration in PPMS. Our findings emphasize to interpret the impairment of rich-club connections as disease specific and disability related. The insensitivity of global graph metrics has been described before.
In vitro, we found the pregnancy hormone progesterone to robustly increase Treg frequencies via promiscuous binding to the glucocorticoid receptor (GR) in T cells.
However, especially spinal cord pathology in this patient group might influence disability by means of the EDSS and mobility assessment and make the interpretation of our association results more difficult.
S.), University Medical Center Hamburg-Eppendorf, Germany. From the Institut für Neuroimmunologie und Multiple Sklerose (INIMS) (J.-P. Not including relapsing-remitting patients limits the generalization of our findings, but we were primarily interested in neurodegenerative aspects of MS and thus aimed to restrict the influence of acute inflammatory disease activity as much as possible by studying a PPMS cohort.
Our analysis followed the original analysis of the rich club that restricted the topological analyses to cortical regions.
and in our data set, the global connectivity did not differ between patients and controls.